Alexander Shulgin is the world’s foremost “psychonaut.” The 82-year-old chemist has not only created more of the 300 known consciousness-altering (or psychoactive) compounds than anyone living or dead, he has, by his own account, sampled somewhere between 200 and 250 of them himself—most of them cooked up in the musty lab behind his home in the hills east of Berkeley, Calif., where he has shared many a chemical voyage with his wife of 26 years, Ann.
“I take them myself because I am interested in their activity in the human mind. How would you test that in a rat or mouse?” says Shulgin, known to friends as Sasha.
He has paid the price for his avocation. Some of his creations have induced uncontrollable vomiting, paralysis and the feeling that his bones were melting, among other terrors. And though some believe Shulgin has opened the doors of perception to a new class of potentially therapeutic mind-altering compounds, others argue that he bears responsibility for the damage that ongoing abuse of such now-illicit substances can cause.
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