Archive for the ‘Pandemics’ Category

India culls 3.4m birds but fails to contain avian flu outbreak

Friday, February 8th, 2008

India is struggling to contain its worst avian influenza -epidemic, in spite of culling 3.4m birds and setting up a 5km poultry exclusion zone round the state of West -Bengal, the epicentre of the outbreak.

The government’s failure to reassure farmers that they will receive fair compensation for birds culled by rapid response teams has left experts scrambling to stop the disease entering the crowded markets of Calcutta and Delhi and led to a crisis of confidence in India’s -poultry industry.

The latest outbreak of the H5N1 strain of bird flu, confirmed on January 15, is proving more difficult to contain than earlier manifestations at large poultry farms in the states of Maharashtra and Gujarat in 2006 and, last year, in Manipur.

Roughly 80 per cent of rural households in West Bengal keep hens and ducks in their backyards to supplement their incomes, a practice encouraged by the state government, which distributes millions of chicks to poor communities each year.

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A Pandemic That Wasn’t but Might Be

Saturday, January 26th, 2008

Last year, for the first time since avian flu emerged as a global threat, the number of human cases was down from the year before. As the illness receded, the scary headlines — with their warnings of a pandemic that could kill 150 million people — all but vanished.

But avian flu has not gone away. Nor has it become less lethal or less widespread in birds. Experts argue that preparations against it have to continue, even if the virus’s failure to mutate into a pandemic strain has given the world more breathing room.

There were 86 confirmed human cases last year compared with 115 in 2006, according to the World Health Organization, and 59 deaths compared with 79. Experts assume that the real numbers are several times larger, because many cases are missed, but that is still a far cry from a pandemic.

Dr. David Nabarro, the senior United Nations coordinator for human and avian flu, recently conceded that he worried somewhat less than he did three years ago. “Not because I think the threat has changed,” he quickly added, but because the response to it has gotten so much better.”

The world is clearly more prepared. Vaccines have been developed. Stockpiles of Tamiflu and masks have grown. Many countries, cities, companies and schools have written pandemic plans. The European Center for Disease Prevention and Control, created in Stockholm in 2005, just estimated that the European Union needed “another two to three years of hard work and investment” to be ready for a pandemic, but that is improving because previous estimates were for five years.

In the worst-hit countries — all poor — laboratories have become faster at flu tests. Government veterinarians now move more quickly to cull chickens. Hospitals have wards for suspect patients, and epidemiologists trace contacts and treat all with Tamiflu — a tactic meant to encircle and snuff outbreaks before the virus can adapt itself to humans.

Bernard Vallat, director general of the World Organization for Animal Health, recently called the virus “extremely stable” and, thus, less likely to mutate into a pandemic form. Many prominent virologists would vehemently disagree. But others who argued three years ago that H5N1 would not “go pandemic” are feeling a bit smug.

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– Ah yes, I believe they were quite smug on the Titanic as well.

– This article is from the NY Times and they insist that folks have an ID and a PW in order to read their stuff. You can get these for free just by signing up. However, a friend of mine suggests the website bugmenot.com :arrow: as an alternative to having to do these annoying sign ups. Check it out. Thx Bruce S. for the tip.

Bird flu outbreak nears Calcutta

Saturday, January 26th, 2008

The bird flu epidemic in the Indian state of West Bengal has inched closer to the capital, Calcutta, with an outbreak reported close to the city.

Tests on dead birds from Balagarh, less than a two-hour drive from Calcutta, have tested positive for the disease.

Nine of the state’s 19 districts have been already hit by the flu. Officials say more than 2m birds would be culled.

The H5N1 strain of bird flu is regarded as highly pathogenic and can also cause disease and death in humans.

Health experts have warned that the outbreak could get out of control.

No cases of human infection have still been reported though a member of the culling team has been admitted to hospital with respiratory disorder and fever.

State animal husbandry minister Anisur Rehman said the government had a “long way to go” in culling the targeted two million birds.

Only a third of the target has been achieved – barely 700,000 birds have been culled in the last 10 days.

“More culling teams are needed in all the affected districts but these are things that cannot be hurried. The men in the culling teams have to be quarantined first before they can be asked to start the operations,” Mr Rehman said.

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India’s Avian Flu Outbreak Is `Serious,’ WHO Says

Thursday, January 24th, 2008

Jan. 23 (Bloomberg) — An outbreak of avian flu in India’s West Bengal state is “serious” and the virus has spread rapidly to many districts, the World Health Organization’s representative said.

The outbreak is the 10th in India since the H5N1 avian influenza virus was first reported to have killed poultry there in February 2006. No human cases have been recorded in India.

India has the capacity to handle the situation as the “fundamentals of planning are sound,” S.J. Habayeb, the organization’s representative in the South Asian nation, said in an interview conducted over e-mail.

The disease has spread to more districts in West Bengal, taking the total number to nine, Farm Minister Sharad Pawar said in New Delhi today. “We are trying to control the situation.”

The government has stepped up culling, with the total number of chickens killed almost doubling to 414,597 today from the 242,200 reported yesterday, according to the agriculture ministry. India confirmed the disease among poultry in the state on Jan. 15.

As many as 116,203 chickens have died from the virus, the ministry said in the release. Samples from six districts have tested negative. About 258 teams have been deployed for culling and surveillance operations in West Bengal, the ministry added.

`Backyard Culling’

“The main problem we are facing is culling in the backyards,” Anisur Rahman, West Bengal’s animal resources minister, said in a telephone interview from the state capital of Kolkata, also known as Calcutta. “In other places, where the disease was reported, the farmers carried their poultry to a central farm in a village. Here, volunteers have to go to each house and convince farmers to do the culling.”

The teams, working in the villages, have gone up from 400 to 650 today, Rahman said.

“Culling is going on at a rapid pace,” he said. “At the same time, we are faced with a situation where poultry is being tested positive from new areas which are far-flung.”

The virus is known to have infected 351 people in 14 countries since late 2003, killing 219 of them, the Geneva-based World Health Organization said on its Web site two days ago. Indonesia has the highest number of fatalities, with 97 deaths.

Millions could die if the H5N1 virus develops the characteristics of seasonal flu and begins spreading easily between humans through coughing and sneezing.

Early signs of the disease range from fever and coughing to diarrhea and vomiting, researchers said in a Jan. 17 report in the New England Journal of Medicine.

Original article…

W Bengal bird flu ‘is spreading’

Thursday, January 24th, 2008

Officials in the Indian state of West Bengal say that the bird flu epidemic has spread to two more of the state’s 19 districts, taking the total to nine.

They say that the spread of the H5N1 virus means that even more chicken and duck will have to be killed than was originally estimated.

On Monday officials said that around 2m birds would need to be culled – a figure that will now rise.

Health experts have warned that the outbreak could get out of control.

The H5N1 strain of bird flu is regarded as highly pathogenic and can also cause disease and death in humans.

However, most human victims have contracted the disease through close contact with affected birds.

There is little evidence that the virus can be transmitted easily between humans.

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– “There is little evidence that the virus can be transmitted easily between humans.” Many scientists studying the H5N1 virus feel that the virus could be one or two mutations away from developing a form that would travel easily from human to human – similar to what happened in 1917 when the Spanish Flu swept the world and killed millions.

– See: &

U.S. Military Begins Planning for Avian Flu Pandemic

Friday, May 18th, 2007

– I’ve published before on the potential for global problems as a result of pandemics. Previous posts: 1, 2, 3, 4, 5, 6, and 7.

– Such pandemics are just one of the elements in the Perfect Storm Hypothesis.

– Especially worrying is the potential for an outbreak of Avian Bird Flu. This virus (H5N1) currently infects humans only very rarely and usually only after very close contact with infected birds. But, the scientists have been saying for several years now that just a single mutation in the current virus could give it the ability to move easily from human to human. The flu pandemic that swept the world in 1917/1918 was just such an event wherein an avian virus mutated so that it could easily infect humans and the result was more people died in the resulting pandemic than died in WWI.

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Bird Flu Virus - H5N1

WASHINGTON (AFP) – The US military has begun to plan for a possible avian flu pandemic that could kill as many as three million people in the United States in as little as six weeks, a Pentagon planning document said.

The Defense Department’s “Implementation Plan for Pandemic Influenza,” which was posted Wednesday on a Pentagon website, lays out guidelines and planning assumptions for US military services and combatant commands.

Possible scenarios include US troops being called in to put down riots, guard pharmaceutical plants and shipments, and help restrict the movement of people inside the country and across its borders.

The plan envisions fast moving, catastrophic waves of disease that would overwhelm health facilities and cripple the ability of state and local authorities to provide even basic commodities or services.

“A pandemic in the United States could result in 20-35 percent of the population becoming ill, three percent being hospitalized, and a fatality rate of one percent,” the document said in a section on “planning assumptions.”

A human-to-human outbreak of avian flu was most likely to occur outside the United States and may not be contained effectively, it said.

“A pandemic outbreak will last between 6-12 weeks and multiple pandemic waves will follow,” it said.

If a pandemic influenza starts outside the United States, it will enter the US at multiple locations and spread quickly to other parts of the country, according to the report.

A vaccine for the specific strain of flu would not be available for distribution for a minimum of six to nine months after a human-to-human outbreak had been clinically confirmed, it said.

Transportation within states or internationally will be restricted to contain the spread of the virus, and communities may voluntarily close schools and limit public gatherings.

“Quarantine and other movement restrictions, especially if the restrictions are involuntary, will have minimal effect on the spread of the disease due to a very short incubation period and the ability of asymptomatic individuals to shed the virus,” the document said.

“Military and civilian medical treatment facilities will be overwhelmed,” it said.

It said the military will be called on to evacuate non-infected people from areas abroad that are having problems, and to help allies.

But the guidance said the US military’s top priority would be to preserve the operational effectiveness of the Defense Department and its forces around the world.

Additionally, the Defense Department will develop a plan to ensure the continuity of operations of the US government and be prepared to support civilian authorities with medical supplies, airlift and security forces.

A key military role will be to distribute medical supplies and medications and provide security for the production and shipment of vaccines on orders of the president.

“When directed by the president, DoD will provide support to civil authorities in the event of a civil disturbance,” the document said. “DoD will augment civilian law enforcement efforts to restore and maintain order in accordance with existing statutes.”

The military also may assist civil authorities in “isolating and/or quarantining groups of people in order to minimize the spread of disease during an influenza pandemic,” it said.

To the original:

– thanks to Kevin at The Cryptogon for this story.

New flu strains ‘resisting drugs’

Monday, April 9th, 2007

New strains of the flu virus are showing resistance to drugs that experts had hoped would slow the spread of any pandemic, research suggests.

Tamiflu is viewed as the best weapon currently available against a flu pandemic, and is being stockpiled by governments including the UK’s.

But Japanese researchers found evidence of emerging resistance to Tamiflu, and a second drug Relenza.

The study is published in the Journal of the American Medical Association.

Experts have warned that a flu pandemic could claim millions of lives around the world.

There is concern that the H5N1 strain of the virus – known as bird flu – could mutate to gain the ability to spread easily from person to person.

At present the virus, a type of the A strain of flu, does not have this ability, although it has killed 170 people since 2003. These were mainly poultry workers, who came into very close contact with infected birds.

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First bird-flu vaccine less effective than thought

Tuesday, February 27th, 2007

WASHINGTON (AP) — The nation’s first vaccine against bird flu is even less effective than previously thought, according to Food and Drug Administration documents released Monday.

In clinical trials, the two-shot series appears to provide protection to just 45 percent of adults who received the highest dose of the Sanofi Aventis SA vaccine.

An earlier, interim analysis of the same study of the vaccine suggested it sparked a protective immune response in 54 percent of patients, when measured 28 days after getting the second shot. The New England Journal of Medicine published those results in March 2006.

The FDA released the more recent results, contained in company and agency documents, ahead of a Tuesday meeting where it will ask a panel of outside experts to review the vaccine. The agency isn’t required to follow the advice of its advisory committees, but usually does. The vaccine is the first against the H5N1 influenza strain to seek FDA approval.

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Bans on UK poultry amid flu cull

Monday, February 5th, 2007

HOLTON, England (Reuters) — Russia and Japan banned British poultry imports as Britain pressed ahead with a cull of 160,000 turkeys after the nation’s first outbreak of a deadly strain of bird flu in farmed poultry.

Workers wearing white protective suits, black gloves and masks loaded the turkeys into crates to be gassed following the discovery of the highly pathogenic H5N1 strain of avian flu on a farm at Holton in eastern England run by Europe’s largest turkey producer, Bernard Matthews.

Farm workers were offered anti-viral drugs and restrictions were imposed on the way birds are housed or moved in a wide area surrounding the farm.

The outbreak had an immediate impact on Britain’s poultry industry, the second largest in the European Union after France.

Russians officials said Moscow would ban British poultry imports from Tuesday to prevent the spread of bird flu. Japan also banned British poultry imports while Ireland barred the import of poultry from Britain for “gatherings and shows”.

The European Union’s top health official said he was optimistic the bloc would be able to control bird flu this year despite outbreaks of the H5N1 strain in Britain and Hungary.

But EU Health and Food Safety Commissioner Markos Kyprianou added: “The virus is still around. We should never feel that we are safe.”

The H5N1 virus has spread into the Middle East, Africa and Europe since it reemerged in Asia in 2003 and outbreaks have now been detected in birds in around 50 countries.

It remains largely an animal disease, but can kill people who come into close contact with infected birds. It has killed 165 people over the past four years, a 22-year-old woman in Nigeria being the latest confirmed victim.

Sixty-three people have been killed in Indonesia, the country worst affected.

Scientists fear the virus could spark a pandemic in which millions die if it mutates into a form that passes easily from person to person.

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Team Discovers Key Step In Flu Virus Replication

Thursday, December 28th, 2006

– The H5N1 Avian Flu Influenza virus is a latent plague just waiting to break out if and when it mutates into a form which can easily jump from human to human. I’ve written about this here: , and . So, any iinsights into how it works and how it can be subverted is great news.
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Science Daily As public health officials around the world keep a nervous eye on the spread of avian influenza, the University of Saskatchewan’s Vaccine and Infectious Disease Organization (VIDO) has uncovered a key step in how the influenza virus causes infection.

Yan Zhou and her team have discovered how a crucial pathway that supports the influenza A virus’s ability to reproduce itself is activated, a finding that could pave the way for new drugs and vaccines.

The paper will appear in the January 2007 issue of the Journal of General Virology and recently has been given advance on-line publication.

“The work we are doing will be applicable to all influenza viruses, including influenza A virus subtype H5N1,” said VIDO Director Lorne Babiuk.

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